General Information

  • ID:  hor002342
  • Uniprot ID:  P17685
  • Protein name:  Acidic peptide
  • Gene name:  ELH1
  • Organism:  Aplysia parvula (Dwarf sea hare)
  • Family:  Molluscan ELH family
  • Source:  animal
  • Expression:  Bag cell neurons.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SSEVALAASDKGDEERELLNTLSNLLE
  • Length:  27
  • Propeptide:  MGRPSYRSAAAISLLMCLILSALCASSESAVVHGSSFATERAVKSSPYLVLSPADEMVGMSTANEAFDKSPSYYDDDDDDFVKNEKRRLRFHKRRIRFNKRPQEVSGLKPVMMSRASASADENSLFDLYNTDGAMYQRDLRAPRLRFYSLRKRAAGDEDKSEENNPETESHSRRKRSALTPSIRSLRSSLESGIAKRISINQDLKAIADMLIVEQKQEREKYLADLRQRLLNKGKRSSEVALAASDKGDEERELLNTLSNLLE
  • Signal peptide:  MGRPSYRSAAAISLLMCLILSALCASSES
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  ELH acts as a neurotransmitter locally, upon neurons of the abdominal ganglion and as a hormone by diffusing into the circulating hemolymph and modulating the activity of other organs. It specifically causes contraction of smooth muscle in the ovotestis and expulsion of the egg string.; Alpha-BCP decreases the activity of a cluster of neurons in the left upper quadrant of the abdominal ganglion.; Beta-BCP specifically excites 2 neurons, L1 and R1, in the abdominal ganglion.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P17685-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002342_AF2.pdbhor002342_ESM.pdb

Physical Information

Mass: 336808 Formula: C121H203N33O49
Absent amino acids: CFHIMPQWY Common amino acids: L
pI: 3.76 Basic residues: 2
Polar residues: 8 Hydrophobic residues: 10
Hydrophobicity: -43.7 Boman Index: -6148
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 108.52
Instability Index: 2653.7 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  NA
  • Title:  NA